Other organs are also sensitive to radiation, and persistent uptake due to inflammatory change can persist for up to 1 year.
Important related aspects are the ease and flexibility of surface functionalisation in order to achieve stabilisation in physiological conditions as well as fast, high and persistent uptake in the target tissue.
Post-therapy scanning was carried out to confirm persistent uptake of I-MIBG.
Tc m-MIBI uptake remained unchanged during conventional chemotherapy but following high-dose chemotherapy, nine of ten patients in complete remission had negative MIBI images whilst five of six with progressive disease demonstrated persistent uptake.
Although this compound showed minimal internalization in prostate cancer cells, it demonstrated very high and persistent uptake in PC-3 human xenografts in nude mice (15.61 ± 1.19%ID/g at 4 h) [ 72].
By contrast, clathrin independent endocytosis has largely been defined by morphological criteria, and by the persistent uptake of cargoes that may utilise multiple pathways following perturbation of the clathrin machinery (Saslowsky et al., 2010; Engel et al., 2011; Cho et al., 2012).
