Animal and experimental studies suggest that DNA damage coupled with insufficient DNA repair during childhood or adolescence may induce epigenetic and translational modifications that have persistent effects in the breasts [ 48, 49].
This finding might lead to reconsider the role of the liver in persistent hyperlactatemia, and opens new perspectives for translational and clinical research on a complex potential resuscitation target, such as lactate.
We demonstrated that the incomplete chlamydial developmental cycle which occurs during low temperature induced persistent infection does not prevent PmpD post-translational processing.
To determine if penicillin directly suppresses serine proteases [23] or blocks the conversion from RBs to EBs [24], [25], PmpD post-translational processing was studied during persistent chlamydial infection induced by low (28°C) temperature.
Persistent uni- or multisegmental instability produces rotational and translational subluxation, resulting in degenerative spondylolisthesis [46].
This new integrated model of effective translational teams holds promise for addressing thorny and persistent health disparities, is consistent with the nation's strategic priority of eliminating health disparities, and bodes well for increasing healthcare effectiveness aimed at better health for all.
However, persistent PERK signaling could ultimately impair cell viability if extended translational inhibition interrupted the generation of proteins vital for cellular homeostasis.
Together, these results suggest HDACs may serve as critical memory suppressor genes and show that HDACi, such as butyrate, may generate more persistent forms of long-term memory, which has great therapeutic and translational value.
The persistent activation of HSF1 involves an alcohol-specific set of post-translational modifications.
To explore the domain-general risk factor of early-life social stress in mental illness, rearing rodents in persistent postweaning social isolation has been established as a widely used animal model with translational relevance for neurodevelopmental psychiatric disorders such as schizophrenia.
