Our data are crucial for the understanding of mechanisms by which mRNA translation promotes persistent hypersensitivity after nerve injury.
HDL identifiers are provided by the Handle System [27], which is a service for performing translation between persistent identifiers and actual up-to-date URIs.
This paper describes the DRUID architecture composed of these three parts (recursive block, translation tables, persistent state), and highlights its goals and benefits, including unifying the data, control, management, and security planes currently considered orthogonal aspects of network architecture.
Although it is not understood mechanistically, addiction is thought to depend on molecular and cellular adaptations that lead to persistent changes in transcription, translation, and synaptic morphology [3], [4].
In addition, the persistent inhibition of protein translation results in loss of synaptic proteins that are essential for neuronal function.
The poor activity of aminoglycosides against persistent bacteria has been attributed to insufficient PMF, since translation occurs in persister cells at a reduced rate.
The OODBMS manifesto [8] stated that persistence should be orthogonal, i.e., each object, independent of its type, is allowed to become persistent as such (i.e., without explicit translation).
In cells lacking eIF5A, persistent global protein synthesis may delay the reprogramming of translation that helps cells recover from adverse environmental conditions.
The persistent shortages of PMTCT supplies also indicate barriers in translation of research findings into action plans to address such inadequacies.
An understanding of the transcription and translation of leaderless mRNAs may provide insights into persistent infection with M. tuberculosis and uncover strategies for drug discovery.
