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These results were supported by FUBAR [ 33], which detected persistent sites of positive selection at codons 106, 112, 118 and 135, also detected by MEME (Additional file 9: Table S4).
Intriguingly, the two intergenic persistent sites of methylation difference flank a binding site for the early growth response 1 (EGR1) transcription factor identified previously in erythroid cells (see Additional file 2: Figure S3) [ 56].
Similar(57)
Neuropathic foot ulcers are treated by 'offloading' or pressure redistribution to relieve persistent pressure to sites of injury.
Microglia undergo persistent activation at sites of white matter damage (Wilson et al., 2004), which may explain why they are observed in densely connected subcortical structures.
It is important, therefore, to be able to precisely localize sites of persistent disease.
The increased levels of CD40 seen in diseased tissue and cholangiocarcinoma could be explained by high local levels of proinflammatory cytokines such as TNFα and IFN-γ at sites of persistent chronic inflammation [14].
Failure to clear all senescent cells could leave sites of persistent secretion of inflammatory molecules.
Impaired coronary vasodilatory response to intracoronary injection of acetylcholine [ 4, 5] and nitroglycerine [ 3, 5] has been demonstrated at sites of persistent and regressed aneurysms.
Peripheral joints in RA and myelin sheets in the central nervous system in MS are the sites of persistent inflammation that leads to tissue destruction.
CODEML predicted two additional sites of persistent positive selection in both IFITM3 and 10 (2 in the N-terminus) (Additional file 10: Table S5).
Nevertheless, It has been shown that teeth with sites of persistent inflammation have 63.4%50-year50-yearval rate compared to 99.5% in teeth with no inflammation [ 13].
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