Sentence examples for persistent regulation from inspiring English sources

Also, evidence is provided for a late (i.e. the effect only appeared hours after the treatment) and a persistent regulation (i.e. maintenance of the effect for several hours) of Akt, ERK and PKCδ phosphorylation by the FA.

Thus, the persistent negative regulation of TSHα gene in α-23 cells in the face of cAMP-mediated stimulation may explain the clinical observation of a rapid decrease in TSH levels after acute T3 administration in hypothyroid patients [32].

However, the fact that in patients with severe COPD there is persistent down regulation of CD46 mRNA after the noxious irritant has been removed, indicates dysregulation at the transcriptional level, perhaps due to polymorphisms or latent viral infections such as measles or adenovirus [41].

Recent work has established that DNA methylation is altered in epilepsy and that these molecular changes contribute to persistent gene regulation in the hippocampus.

Preclinical studies have shown that repeated or continuous treatment with antimigraine drugs result in persistent up-regulation of neurotransmitters within the orofacial division of the trigeminal ganglia and in the development of CA in response to migraine triggers, even weeks after discontinuation of the antimigraine drug [7].

Thus, CIE-induced DNA demethylation may contribute to the persistent up-regulation of NR2B gene transcription.

This provides strong support for our hypothesis that DNA methylation mediates CIE-induced persistent up-regulation of NR2B gene transcription.

At the protein level, however, a persistent up-regulation of BiP was found at 24 h (Fig. 1D).

Persistent up-regulation of NR2B gene expression by chronic intermittent alcohol treatment may serve as one mechanism underlying ethanol dependence behaviors.

Recent work in our laboratory and that of others has shown that CIE induces persistent up-regulation of NR2B gene expression and function [15], [16], [17].

It has been shown that levels of the p75 neurotrophin receptors (NTR) are upregulated in neurons, while there is a persistent down-regulation of tyrosine-related kinase receptors (TrkRs) in the injury vicinity [27].