For example, a 5 d Bisphenol A (BpA) exposure in neonatal male rats induces persistent ESR1 promoter hypermethylation in adults, associated with increasing levels of Dnmts.
Several years ago, Li et al [30] demonstrated that fetal exposure to DES elicits demethylation of a single CG site in the lactoferrin promoter with persistent overexpression of the gene in mature mouse uteri.
In line with these reports, our studies identified NAV3 as a promoter of persistent migration and a suppressor of breast cancer progression.
Chronic PDE inhibition, via the persistent activation of PDE5 promoters, may up-regulate PDE expression and, therefore, be associated with the development of drug tachyphylaxis (Moreland et al 1999).
In addition, we further confirmed that the TBG promoter confers transgene persistent and specific expression within the liver up to several months after integration.
Finally, they used an adeno-associated virus vector (AAV2/8) which preferentially targets liver and incorporated the thyroxine-binding globulin promoter to achieve persistent high-level expression in liver.
Epigenetic imprints predicted observed deviations from transcriptional timing in emerin null cells, with persistent suppressive chromatin state on myog promoter upon myogenic induction and failure to appropriately establish repressive histone marks (H3K9me3) on Tk1 promoter (cell cycle).
The painted Simpson is publicising a film, but the promoters promised that the persistent summer rains would wash him away.
This smoking-induced long-lasting effect was due to demethylation of the MAOB gene promoter which resulted in a persistent high protein concentration of platelet MAO-B.
The role of persistent infection by HPV as a tumor promoter in uterine cervical cancer induction has been recognized [ 33- 37].
Despite persistent methylation of the O 6 -methylguanine-DNA methyltransferase promoter, BTL3 cells exhibited the highest temozolomide sensitivity.
