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However, antiviral treatment only partially interferes with the B-cell activities responsible for the persistent production of cryoglobulins, because cryoglobulinemic vasculitis persisted in one series of patients treated successfully for HCV infection [ 50] and who relapsed, despite the achievement of a biologic response by another group of treated patients [ 51].
It also resonates with the persistent production of low-latitude geomagnetic flux patches below Indonesia during the historical era (Jackson et al. 2000).
Activation of BV2 microglial cells by LPS exposure stimulated significant and persistent production of NO, IL-1β, IL-6, and TNF-α.
The main cause of invasive cervical cancer is the deregulated and persistent production of HPV E6 and E7 oncoproteins [14].
Smoking and persistent production of inflammatory mediators from the lung are inducers of systemic inflammation.
After therapy, a persistent production of high levels of inflammatory cytokines can confer a poor prognosis.
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However, over time microglial cells lose their protective role, due to the persistent production and accumulation of proinflammatory cytokines within their microenvironment [ 65].
The "activated" fibroblast and its contractile and secretory counterpart, myofibroblast, are the primary cell types responsible for the persistent production and deposition of ECM.
Persistent IFN signaling, production of inflammatory cytokines, ER stress and possibly a feed-forward loop among them are likely to exacerbate intestinal inflammation.
But there has also been a prolonged, on-going, persistent and extensive production of false motif literature that confounds attempts to understand regulatory systems [ 6].
The residual toxicity exhibited as general stress, membrane stress, and oxidative stress after 30 and 60 min electro-Fenton transformations of bisphenol A indicated the potential production of persistent toxic products.
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