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Treatment at baseline and during follow-up did not differ between them, suggesting that greater clinical improvement in persistent patients was probably related to persistence on therapy.
Using a 90-day gap to define insulin persistence increases the likelihood of falsely classifying persistent patients as non-persistent.
However, there was no significant difference in gender or baseline mean A1C by persistence groups, and a higher percentage of persistent patients had dyslipidemia (84% vs. 78%, p = 0.007) and non-alcoholic fatty liver disease (5%vs.2%2%, p = 0.012) than did non-persistent patients (Table 1).
Persistence was also improved in patients receiving weekly bisphosphonates, assessed by both length of persistence (194 269 days [weekly] and 134 208 days [daily]) and percentage of persistent patients at the end of the follow-up period (35.7% 69.7% [weekly] and 26.1%55.7%% [daily]).
Step C3 (Moderate persistent): Patients with 60%< FEV1<80% predicted, or daily attacks Step C4 (Severe persistent): All patients with FEV1< = 60% predicted.
Differences between persistent and non-persistent patients mirrored those of the adherent vs. non-adherent cohorts for several characteristics, including age (persistent patients were slightly older) and mean DCSI (no difference between persistent and non-persistent patients).
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Current attempts to limit the access to newer antihypertensive drug classes [ 35] have to fail in reducing the overall cost impact of hypertension, if persistence with treatment as well as non-drug costs of non-persistent patients are not taken into account.
Braun et al. [15] investigated newly diagnosed ADHD patients as well, but for subgroup analyses of treatment-persistent patients compared with a drug treatment-nonpersistent group and nondrug-treated patients.
Furthermore, non-persistent patients had significantly lower total healthcare costs.
Non-persistent patients were those with a gap in therapy of >90 days.
Persistent and non-persistent patients were compared using standard tests of statistical significance.
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