Sentence examples for persistent pathway from inspiring English sources

"If we're showing that genes have an overwhelming influence on who gets put onto the life-course persistent pathway, then that would suggest we need to know which genes are involved and, at the same time, how they're interacting with the environment, so we can tailor interventions," Dr. Barnes said.

The life-course persistent pathway from childhood to adult disorders may be best interrupted early in life, when these behavioral patterns are more easily modified [ 11].

Indeed, overexpression of B9L and BCL9 may contribute to, or even confer, persistent pathway activity that is independent of Wnt ligand, for example in colorectal tumours whose progression may thus be promoted by these proteins.

Nitrate had the slowest relaxation time, suggesting a persistent subsurface pathway and the effect of nitrification.

Whether these long-lasting levels of plasma sRAGE reflect persistent RAGE pathway activation and thereby contribute to the perpetuation of inflammation in critically ill patients merit further studies.

Generally, Odgers et al. [ 5] concluded that those on an early-onset persistent antisocial pathway fared the worst with regard to mental and physical health problems and economic situation at age 32.

However, excessive or persistent Hh pathway activity actually aborts successful regeneration of damaged liver tissue and contributes to the pathogenesis of liver fibrosis by promoting EMT (while inhibiting MET) [ 22].

As discussed later, we suspect that the net effect of this miRNA targeting is to keep signaling through the Wnt pathway persistent and chronic, leading to effective disease progression and persistence.

Further, a short overview of indicated disease pathologies will be given and the impact of IL-6 in JAK/STAT pathway, persistent STAT3 activation and cancer immunotherapy will be discussed.

NF-κB subunits are often activated in solid or hematological malignancies as the result of rearrangements/mutations in their genes or in genes encoding components of the NF-κB signaling pathway, persistent autocrine or paracrine stimulation through specific cell surface receptors, or viral or cellular oncoprotein activity (for review see [2], [3]).

For persistent offenders, the pathway is not linear but often cyclical as they may move through stages multiple times (see Figure 1).