Our study demonstrates that a large segment of the general population has been infected by STLPyV and might harbor persistent STLPyV infection, assuming the persistence paradigms of JCPyV and BKPyV hold true for STLPyV.
But he changed it for me, not only because of how he succeeded but because it helped me see what I had been missing all along: the evidence of invention, the persistent reminder of paradigm shifts.
The gastric pathogen Helicobacter pylori is a paradigm of persistent bacterial infections and chronic inflammation in humans.
More recently, Neuhaus et al. (2006), using an auditory oddball paradigm, reported persistent P300 amplitude reduction in smokers and furthermore, even in former smokers [ 18].
We have previously observed this persistent activation using a paradigm in which animals were exposed to two periods of noise stress (one on day 7 10 of lactation and the other 3 days later after removing the pups) (18).
A new paradigm for persistent asthma is emerging of a damaged epithelium that repairs incompletely and leads to a chronic wound scenario with the secretion of a range of growth factors capable of driving structural changes linked to airway remodeling [ 127- 129].
For instance, Pych et al. reported that rats exhibiting 93% alternation in a Y-maze paradigm used a persistent turning strategy [ 16].
Elevated serum U6 levels in breast cancer patients irrespective of disease activity at the time of serum collection suggest a new paradigm in cancer; persistent systemic changes during cancer progression, which result in elevated activity of RNAP-III and/or the stability/release pathways of U6 in non-cancer tissues.
Cure experiments are proof-of-concept studies designed to evaluate novel paradigms to reduce persistent HIV-1 reservoirs, without any expectation of medical benefit.
This probably is due to a persistent interest in alternative formal paradigms, to the controversial features and axioms of Principia Mathematica, and to the problematic place that self-reference occupies in mathematical logic.
