Sentence examples for persistent mutation from inspiring English sources

For the genes in each cluster (rows), shown are their mutated occurrences in each patient (columns); green: gene is persistently mutated in patient, white: no persistent mutation, yellow circle: driver mutation.

Only one (S306F) of the five persistent mutations is close to the active site.

The other four persistent mutations are near the surface of the enzyme.

Four rounds of directed evolution led to the identification of several mutants, with clones in the final rounds containing five persistent mutations.

Persistent mutations (yellow lightning bolt) have likely swept through the population, whereas transient mutations (pink lightning bolt) have not.

All Rec SNP aft Prev: the same as above but restricted to those ORFs that contain persistent mutations in three or more clinical series.

Background mutations (purple) exist in the all isolates; persistent mutations (yellow) are not in the progenitor, but found in all subsequent isolates after their first occurrence; transient mutations (pink) are not in the progenitor and only in some later isolates; recurrently polymorphic genes contain persistent mutations that occur in the same gene in more than one patient (black box).

This will have also biased the type of mutations observed, with persistent mutations appearing to be more prevalent than those which rapidly become undetectable such as K65R or M184V.

Persistent mutations (yellow lightning bolt) have risen in the population to a frequency that they are repeatedly sampled (large circles) whereas transient mutations (pink lightning bolt) have not (small circle).

Moreover, the results suggest that proliferation of prostatic epithelial cells in the milieu of oxy-radical barrage may result in conversion of DNA damage to persistent mutations, some of which may provide prostatic cells with growth and/or antiapoptotic advantage.

The restoration of normal LV 1 5 width indices in db/db mutants following E2-HRx indicates that correction of the glucometabolic disturbances with characterize the hypogonadal mutant model [ 28- 30] re-establishes osteomaturation indices under persistent missense mutation (Table 1) expression influences [ 15, 16].