Sentence examples for persistent localization from inspiring English sources

At 15 hpf, HP1ß signals became absent in untreated PN embryos, while a persistent localization of HP1ß was detected in PJ-34 treated embryos (Figure 6C).

In contrast, the Uba80-GFP transfected cells showed persistent localization of GFP in the nucleoli.

This revealed for the first time a persistent localization of a chitin synthase at septation sites.

Bcl-2 counteracts the effects of BH3-only proteins and its persistent localization in the ER membrane can block apoptosis.

Persistent localization of transitory membrane cargo to TrfR-positive endosomes can be associated with blocked trafficking of EGFR toward the lysosome.

Interestingly, a GAP dead mutant expressed in HeLa cells showed persistent localization to centromeres, and depletion of ECT-2 (the partner GTP exchange factor protein) recapitulated MgcRacGAP depletion.

The highly significant and strikingly persistent chromosomal localization of the differentially expressed genes made us hypothesize about which transcriptional regulation mechanisms can underlie these gene expression patterns.

Persistent MPS1 localization to metaphase kinetochores causes persistent MAD1 kinetochore binding (Jelluma et al. 2010), so MPS1 itself needs to be removed from kinetochores at metaphase to allow MAD1 removal and SAC silencing.

A similar and explicative situation has been described in fission yeast, where the association of the recombination protein MUS81 with stalled forks is actively prevented by Cds1-dependent phosphorylation, and unphosphorylable mutants show persistent chromatin localization [ 47].

In agreement with this, we showed previously that similar tethering of MPS1 prevented anaphase in human cells and this coincided with persistent MAD1 localization to attached, bioriented kinetochores (Jelluma et al. 2010).

However, a significant fraction of GFP-5R-expressing cells displayed persistent kinetochore localization of BubR1 at anaphase and telophase stages, strongly suggesting that Kif18A sumoylation may regulate the removal of BubR1 from the kinetochores and compromise its inactivation.