She had had a persistent fever, which was later linked to chickenpox.
Tick-borne diseases like Lyme and anaplasmosis could cause this kind of persistent fever.
All patients with persistent fever, with or without clinical deterioration, should be investigated for noninfectious causes of fever (Table 4).
Figure 1 Suggested adjustments to the empirical antibiotic regimen in patients with persistent fever after 3-5 days treatment.
For clinically stable patients with persistent fever, there is no published evidence to support a change in the antibiotic regimen.
Failure to respond to empirical therapy is defined as persistent fever and the development of serious medical complications.
Of note, investigators reported that 70.4 % patients had a septic shock, 50.9 % a recent surgery, and 36.0 % a persistent fever.
Six percent of the participants (25/391) required changes in antibiotic therapy, most commonly for persistent fever (6/25, 25%).
Plasma carbapenem levels can be measured by using high-performance liquid chromatography in patients with persistent fever to ensure that the plasma concentrations are within the therapeutic range.
Persistent fever requires adaptation of the initial antibiotic regimen if the clinical condition deteriorates or if a resistant pathogen is isolated.
Two weeks after LA, persistent fever, leukocytosis (13,500/mmc) and increased lipase and C-reactive protein values (380 mg/l) led to repeated contrast-enhanced MDCT.
