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Thus, for persistent elimination of autoreactive LLPCs, existing LLPCs must be depleted (for example, by a cycle of bortezomib), and their regeneration must be prevented by maintenance therapy.
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We speculate that these molecular roles may be relevant to ApoEr2 functions in synaptic plasticity and learning and memory, both of which depend on the dynamic or persistent formation or elimination of synapses and dendritic spines.
Malaria remains one of the most devastating diseases causing high morbidity and mortality despite persistent efforts for elimination.
Dioxins and PCBs are very persistent compounds with elimination half-life in humans ranging from 1 to >20 years [ 7].
They are lipophilic and persistent, and their elimination from the body can take years or even decades [ 3].
Although several PCB congeners are persistent and have elimination half-lives of several years, serum concentrations in children change because of the dilution resulting from an expanded lipid compartment (Grandjean et al. 2008).
Some countries such as Wallis and Futuna had persistent and successful elimination programs for decades, whilst many others have experienced resurgence after reducing microfilaria prevalence to levels below 1% [ 2].
It is hypothesized that in chronic pain conditions this adaptive pain mechanism persists despite elimination of the original nociceptive input and thus provides a deranged pathological mechanism for persistent pain [ 40].
In the present study, only one of 9 MRSA colonizers without successful elimination was persistent colonizer; in contrast, without elimination procedures, nearly two-thirds of 28 MSSA colonizations were persistent.
Advanced Oxidation Processes (AOP) are suggested for the elimination of persistent organic compounds from water matrices.
Therefore, BVD with these economic losses, need to accurate and sensitive diagnostic methods for rapid identification and elimination of persistent carriers in the herds.
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