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The association between aminotransferases and the metabolic cluster is consistent with persistent elevation of ALT and GGT in those with elevated cardiovascular risk in the Bogalusa study (5).
Thus the persistent elevation of TXNIP protein is strictly correlated with the persistency of the elevation of the glucose level and is very sensitive to its magnitude.
Pulmonary arterial hypertension (PAH) is a fatal disease characterized by a persistent elevation of pulmonary artery pressure and ventricular hypertrophy.
Early increases in cardiac troponins (especially within 72 h of treatment) and persistent elevation can herald subsequent cardiac damage [4 6, 24].
Among infected with antibiotic sepsis survivors, we observed persistent elevation of NF-κB in the absence of any obvious infection as shown by culturing flies surviving sepsis.
Persistent elevation of plasma NGAL above 1000 ng/mL on 0 and 12 hours was significantly associated with need for early renal replacement therapy.
Serious adverse events also included an instance of loss of visual acuity ≥6 ETDRS lines in a fellow eye because of persistent elevation of IOP ≥35 mmHg for more than 2 weeks.
The overwhelming inflammatory response associated with ARDS not only targets the lung but also causes persistent elevation of circulating protease and cytokine levels, and primed or hyperactivated neutrophil numbers, leading to extrapulmonary organ dysfunction [2, 33].
The persistent elevation in skin retinoic acid levels could also be due to decreased retinoic acid catabolism.
It is thought that persistent elevation of PDK4 expression during recovery from exercise ensures that glucose entering the cell is preferentially used for muscle glycogen resynthesis [44].
Persistent elevation in firing rates of cortical neurons during retention of memoranda has been suggested to represent the neuronal correlate of working memory [1] [3].
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