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However, deficiencies in humoral response because of depleted or persistent defects in memory cell function persist after ART initiation.
But on scans, he said, he may see "large persistent defects at the repair site, and in some cases no residual repair at all".
Defects in the annulus fibrosus (AF) remain a challenge in the surgical treatment of lumbar disc herniations with persistent defects, allowing potential re herniation of nucleus pulposus (NP) tissue.
Although Cbl-/-Vav1-/ mice were shown here to have normal T cell development, these mice had persistent defects in homeostasis and proliferation of peripheral T cells, not differing from those seen in Vav1-/ (Fig. 2A, B).
No persistent defects or recurrent erosions were recorded.
However, other studies suggest that treatment failures and a significant amount of persistent defects after healing are often observed [ 56].
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These data are consistent with a persistent defect, not just a delay, in cerebellar development.
Yet, limited reports are available on long-term risk of severe infection; a persistent defect of humoral response to infection by Haemophilus influenzae or to vaccination for Streptococcus pneumoniae, measles, and rubella has been reported [ 11, 16].
Moreover, re-expression of cytosolic FH ameliorates constitutive activation of both the hypoxia and antioxidant response pathways in FH1-null cells, despite a persistent defect in oxidative metabolism (Adam et al., 2011; O'Flaherty et al., 2010).
Over the course of approximately three months the patient's symptoms did not progress without the chemotherapy treatment and the patient ceased to experience any further episodes of inferior altitudinal field defects on the right side (the left side now had a persistent defect).
To expand our findings and to assess directly if cytosolic FH has a functional role in vivo, we generated two FH-expressing transgenic mouse lines (including a cytosolic variant, FHcyt), which we have previously demonstrated to suppress both HIF-1α and NRF2 expression in vitro despite a persistent defect in oxidative metabolism (Adam et al., 2011; O'Flaherty et al., 2010).
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