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In cohort 2, however, the GLA-S and the DET-C subgroups had similar levels of treatment persistence (56.5 vs. 58.5%, respectively; p = 0.292) yet fewer treatment persistent days (320.7 vs. 325.3 days; p = 0.015).
Among patients in cohort 1, those in the DET-S subgroup versus those in the GLA-C subgroup had significantly lower persistence with treatment (52.4 vs. 61.3%, respectively; p < 0.0001) and significantly fewer treatment persistent days (311.6 vs. 331.0 days; p < 0.0001).
Similar(58)
Persistent (day 13 post wounding) expression of the inflammatory cytokines IL-1α and TNF-α was observed in an excisional wound healing model in diabetic (db/db) mice [48].
The oxaliplatin dose was reduced by 25% for subsequent cycles in case of persistent (⩾14 days) or temporary (7 14 days) painful paresthesia or functional impairment.
Persistent (⩾14 days) paresthesia or temporary (7 14 days) painful paresthesia or functional impairment prompted a 25% dose reduction of oxaliplatin.
Oxaliplatin dose was reduced by 15% in cases of persistent (⩾14 days) paresthaesia or temporary (7 14 days) painful paresthaesia or functional impairment.
Oxaliplatin dose was reduced by 15% in case of persistent (⩾14 days) paraesthesia or temporary (7 14 days) painful paraesthesia, or functional impairment.
L-HOP was also reduced by 25% for persistent (⩾14 days) paraesthesia or temporary (7 14 days) painful paraesthesia or functional impairment.
Neuropathy: L-OHP was reduced to 15 mg m−2 day−1 in case of persistent (<14 days) paresthesia or occurrence of functional impairment; ⩾14 days provided L-OHP discontinuation.
Oxaliplatin was reduced to 75 mg m−2 in case of persistent (>14 days) paresthesia or temporary (7 14 day) painful paresthesia or functional impairment.
One in every nine (111, 11.5%) experienced diarrhoea for longer than one week, with 37 (3.8%) individuals suffering from persistent (≥14 days of TD) and 11 (1.1%) from chronic diarrhoea (≥ 30 days).
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