Sentence examples for persistent constitutive from inspiring English sources

Since persistent constitutive DNA replication stress, particularly when paralleled by mTOR signaling, is considered to be the major cause of aging, the present findings are consistent with the notion that metformin, by reducing both DNA replication stress and mTOR-signaling, slows down aging and/or cell senescence processes.

40 Aging is characterized by a constitutive proinflammatory environment in which persistent low-grade innate immune activation could enhance cellular, tissue, and organ damage by HIV infection, including that of the skeletal system.

Importantly, during aging, a persistent shift from BAG1 to BAG3 determines the constitutive activation of the autophagic system for degradation of defective proteins.

Nonetheless, when left unattended, a persistent viral infection combined with a strong and constitutive expression of viral oncoproteins E6 and E7 are highly inductive steps towards the malignant transformation of cervical epithelium [ 5].

Finally, the dynamic damage constitutive model for the rock mass with persistent joints is proposed based on Taylor Chen Kuszmaul (TCK) model.

Importantly, heat shock protein 60 released by tumor cells caused a persistent activation of TLR2 and was critical in the constitutive activation of transcription factor Stat3, leading to the release of immunosuppressive cytokines and chemokines.

Those morphological changes resemble persistent cellular stimulation by oncogene activity, for instance, by constitutive active growth factor receptors.

FCP may be used as a useful fecal inflammatory marker in helping to distinguish between constitutive and immune-inflammatory causes of severe persistent diarrhea of small children [ 40].

An incremental format for an age-dependent constitutive equation was derived to account for the persistent change in creep-causing stress.

Persistent expression of SOCS3 is observed in AML and coincides with constitutive activation of JAK-STAT pathways.

All this evidence collectively indicates that the observed constitutive DNA damage signaling occurs as a response to persistent DNA replication stress.