Sentence examples for persistent breaks from inspiring English sources

However, recent studies pinpoint additional unanticipated functions for ATM in modifying both the local chromatin landscape and the global chromosome organization, more particularly at persistent breaks.

Persistent breaks can in turn lead to genomic instability.

63– 65 Persistent breaks in the immunoglobulin (Ig) heavy chain locus promote translocations, including those with Myc, that are known to promote genesis of lymphoma and occur at higher rates in ATM-deficient cells.

Although DNA double-strand breaks (DSB) have been detected at the site, it is likely that in vivo persistent breaks are rare in undamaged yeast (Fritsch et al., 2010).

"I linked it originally because it's a quick way to give more of an impression of you as a person rather than write an essay on your profile; It's almost like saying: 'Hey, I have friends and do cool stuff.'" It's irritating that women are not able to use the dating app in the way that they want to; women are having to adjust their behavior because persistent men persistently break the rules.

O-mG is subsequently mispaired with another T and the adduct is repaired creating a cycle that ultimately leads to persistent DNA breaks, cell cycle arrest and apoptosis [61,62].

A likely deleterious consequence of responding differently to additional ROS is a greater increase in the presence of persistent DNA breaks and the rapid accumulation of chromosome rearrangements compared to wild type mouse embryonic fibroblasts [ 22].

This indicated that the antitrypanosomal activity of compound 1 is, at least in part, mediated through base modifications recognized by the MMR machinery that lead to persistent DNA breaks.

Indeed, cells with persistent telomeric breaks, or dysfunctional telomeres, have been reported to increase in abundance in an aging-associated manner in tissue of mice (Hewitt et al., 2012), baboon (Herbig et al., 2006; Jeyapalan et al., 2007; Fumagalli et al., 2012), and humans (Suram et al., 2012).

A few hours later, she could hardly rouse herself when a persistent sound broke into her sleep — the doorbell, she eventually determined, never having heard it before.

But of longer-term concern for residents are the growing signs that the city's ambitious favela "pacification" program – which aims to seize back control of slums from drug traffickers – is unravelling as a result of persistent inequality, broken promises, organised crime and police violence.