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If this microcirculatory mechanism is a general one, then drugs other than AVE8062 that produce persistent blockage of blood flow in tumour-feeding vessels should show irreversible TBF stanching, similar to that caused by AVE8062.
Australian New Zealand Clinical Trials Registry (ANZCTR12612000508875) The World Health Organisation's (WHO) current definition of chronic obstructive pulmonary disease (COPD) is a lung ailment fundamentally characterised by persistent blockage of airflow from the lungs [ 1].
Similar(56)
One-sided persistent nasal blockage, especially with purulent discharge, suggests a foreign body or unilateral choanal atresia.
Nasal symptoms usually manifest as persistent nasal discharge and blockage.
Moreover, the precondition of gaining such advantages requires persistent activation of proliferation signal or blockage of apoptosis pathway [ 7, 19].
Upstream signaling pathways involved in the blockage of G2/M transition included lack of persistent Erk1/2 activation and inability to up-regulate the levels of Cdk1, Plk1, Aurora A and B, and Mad2 along with a defective histone 3 phosphorylation and lack of chromatin condensation.
But a persistent problem has been that in many cases, stent insertion causes scarring and renewed blockage.
"Blockage and stoppage.
It involves blockage.
You have an intestinal blockage.
Politics is the main blockage.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com