Sentence examples for persistent binding from inspiring English sources

Specifically, compounds that substitute the O-hexyl chain of xanomeline with polar, ionizable, or conformationally restricted moieties were assessed for their ability to bind to the M1 receptor in a wash-resistant manner (persistent binding).

DDB1 knockdown led to a significant decrease in nuclear CSA-GFP levels, while CSA-GFP levels in the cytoplasm increased (Fig. 4e), likely due to persistent binding of CSA-GFP to TRiC (Fig. 4a).

Results indicate that persistent binding may arise not only from hydrophobic interactions but also from ionic interactions with a secondary M1 receptor binding site.

Furthermore, we found that in CSA-deficient patient cells expressing CSA 8M RRS was reduced when compared to that in cells expressing CSA WT (Fig. 6b), showing that not only CSA instability, but also persistent binding of CSA to TRiC negatively impacts TC-NER.

This requires a persistent binding of both partners.

In particular, Malectin showed persistent binding to extensively oxidized ER-retained HA, which poorly associates with Calnexin.

Chromatographic characterisation of the polymer after functionalisation with amino groups displayed a persistent dynamic binding capacity of 15.5 mg of plasmid DNA/mL.

The authors argue that an initially low reference point raises the likelihood of a persistent and binding internal constraint leading to a poverty trap.

Lack of ubiquitination of NVP protein adducts could lead to more persistent covalent binding and possibly toxicity.

HARP has been shown to play an important role during both DNA replication and repair, and cells lacking HARP exhibit replication defects and persistent RPA binding.

Such a model would explain our biochemical findings, and would also explain our biological data if persistent Mre11 binding to the nascent 3′ terminal DNA impairs HR unless counteracted by the actions of Sae2 or weakened by mre11 SUPsae2 ∆ alleles.