(5) Fothergill, E., Guo, J., Howard, L., Kerns, J. C., Knuth, N. D., Brychta, R., Chen, K. Y., Skarulis, M. C., Walter, M., Walter, P. J. and Hall, K. D. (2016), Persistent metabolic adaptation 6 years after "The Biggest Loser" competition.
Self-administered MA produced a transient striatal DA depletion with a more persistent increase in DA turnover, indicating the presence of some lasting adaptations.
Chronic social defeat stress (CSDS) produces persistent behavioral adaptations in mice.
This was due to persistent peripheral adaptations (larger mixed-arterial/venous O2 difference, and therefore better O2 extraction by skeletal muscle).
Moreover, persistent epigenetic adaptations that occur early in development in response to maternal nutrition and the environment are associated with increased susceptibility to cancer and other adult-onset chronic diseases (Cooney et al. 2002; Li et al. 2003; Waterland and Jirtle 2004).
Persistent fever requires adaptation of the initial antibiotic regimen if the clinical condition deteriorates or if a resistant pathogen is isolated.
Interestingly Duff et al 2008 [4], also found increases in low-frequency spectral power post-task but localised to task-activated regions and suggest that this may reflect persistent intrinsic neural adaptation, or activity associated with consolidation of the practiced motor skill.
If there is a clear separation of affinities, and the low affinity pathway is the faster pathway, then for certain ranges of the input signal, the response of this pathway to a persistent stimulus is adaptive: this adaptation may be close to being exact if enough quantity of the high affinity component is present.
The persistent gap, termed the "adaptation deficit," between the assumed ability of communities to adapt to climate change and the on-the-ground evidence of their progress to adapt is well-documented.
The hypertrophied venous myocardium may reflect adaptation to persistent hypoxemia.
