Sentence examples for persistent activation of from inspiring English sources

Late LTP is induced by changes in gene expression and protein synthesis brought about by the persistent activation of protein kinases activated during E-LTP, such as MAPK.

They also show the persistent activation of particular signaling pathways which are only transiently active in normal cells.

This long-term activity of HSF1 HSF2 heterotrimers depends in fact on the persistent activation of their two components.

Persistent activation of ERK contributes to oxidative neuronal injury in both neurons and astrocytes [34].

Dialysis with 42 mM HEEDTA/0.5 μM free Ca2+caused the persistent activation of lCl(Ca).

In a variety of conditions excessive and/or persistent activation of the innate immune system has detrimental effects.

Growth factor receptors are usually overexpressed or mutated in tumor cells, which results in persistent activation of downstream mitogenic signals.

Persistent activation of the B-cell receptor pathway is critical to the pathogenesis of mantle cell lymphoma.

Overexpression of P62 or increased P62 levels due to defects in autophagy leads to persistent activation of NRF2 [172] 172], contributing to carcinogenesis [173].

Compared with other types of glial cells, such as microglia, significant and persistent activation of astrocytes is a common feature following painful injury [21].

Recent electrophysiological data has provided direct evidence that CSD is a powerful endogenous process which can lead to persistent activation of nociceptors innervating the meninges.