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Persistent activation of p42 mitogen-activated protein kinase (p42 MAPK) during mitosis induces a "cytostatic factor" arrest, the arrest responsible for preventing the parthenogenetic activation of unfertilized eggs.
They also show the persistent activation of particular signaling pathways which are only transiently active in normal cells.
This long-term activity of HSF1 HSF2 heterotrimers depends in fact on the persistent activation of their two components.
Persistent activation and differentiation of Fb drives further maturation of the compact scar tissue.
Persistent activation of ER stress signalling can provoke excessive fat accumulation and insulin resistance14,15.
Murakoshi, H., Wang, H. & Yasuda, R. Local, persistent activation of Rho GTPases during plasticity of single dendritic spines.
Dialysis with 42 mM HEEDTA/0.5 μM free Ca2+caused the persistent activation of lCl(Ca).
This persistent activation is a consequence of the establishment of a mechanical feedback loop, which perpetuates myofibroblast matrix secretion through the sensing and promotion of a stiff microenvironment28.
Ni, H. M. et al. Liver-specific loss of Atg5 causes persistent activation of Nrf2 and protects against acetaminophen-induced liver injury.
The model simulated empirical observations that repeated applications of 5-HT induce persistent activation of protein kinase A (PKA) and that this persistent activation requires a suprathreshold exposure of 5-HT.
Persistent activation of the B-cell receptor pathway is critical to the pathogenesis of mantle cell lymphoma.
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