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We trace back the origins of the research regarding time consistency to Koopmans (1960) who put on the precise mathematical footing, in terms of the utility function, the notion of persistency over time of the structure of preferences.
Considering that the major use of sheep milk is for producing cheese, protein and fat yields, and their combination in the form of useful yield, are important traits, and their persistency over the length of the lactation, enables a more sustained outflow of milk for cheese production [ 43].
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Least square means from the linear regression model suggest higher persistency of accuracy over time for traits with high estimates of π (egg weight, body weight), indicating that the GEBV for these traits capture more information through LD or linkage with QTL, compared to traits which seem to be more polygenic and where markers explain mostly pedigree relationships.
Greater patient persistency with one medication over another would potentially lower the overall cost of therapy with that drug, taking into account the associated cost of additional physician visits if a patient needs to switch to another drug.
9– 11 However, some prostaglandin-treated patients experience conjunctival hyperaemia, 12 and this condition is of concern because this side effect may have a negative affect on whether the patient takes the drug as directed (compliance) and/or continues to use the drug over time (persistency).
Once the mixed model (3) is fitted, the sire NCSS can be used to determine the peak milk yield, the time at which the peak occurs, milk yield persistency, and total milk yield over the full lactation.
Several simulation studies have been carried out to determine which factors affect the persistency of the accuracy of GEBV over generations.
However, identifying the QTL and obtaining a higher persistency of reliabilities of genomic predictions over generations probably requires a large training set of thousands of sequenced individuals.
The estimates for the effect of intermarriage are similar, and I choose the simplest model for the analysis because more variables are likely to make the estimates more imprecise due to the high persistency in income and labour force status over time.
Due to the high persistency of TAP, the advantage of TAP over RRBLUP in accuracy increased from 0.016 in generation 2 to 0.065 in generation 6.
Although using non-linear alternatives (e.g. BayesA, BayesB, BayesR) is not always superior to GBLUP for within-breed prediction, nonlinear methods are expected to improve the persistency of the accuracy of genomic predictions over future generations [ 1, 10].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com