In the persistence phase of the study, two participants of the ACWY-TT group died due to a traffic accident (one subject between Year 1 and Year 2 and a second subject between Year 2 and Year 3).
During the long-term persistence stages of the study, toddlers who did not retain rSBA titers ≥ 1 8 for meningococcal serogroup C and were re-vaccinated against this serogroup were excluded from the analyses performed at subsequent timepoints.
Salinity and pH are some of the factors that could be maintaining its occurrence and persistence of the pathogen in study area.
This introduced a selection bias in the persistence stage of the study since children who did not maintain rSBA titers ≥ 1 8 were excluded, leading to an overestimation of the persistence as the study progressed.
However, it was possible to compare the relative persistence of the various treatments studied here, and the discussion below is based on the modelled data.
The outcomes were subsequently reassessed both in the main study and in UKPDS-HDS after a period of 10 years of extended follow-up under conditions of standard care, to study the possible long-term persistence of the beneficial effects of study interventions beyond the intervention period (9).
Of these, 293, 261 and 223 toddlers were enrolled in the persistence follow-up stage of the study at one, two and three years after vaccination, respectively (Fig. 1).
The high rates of non-persistence contrast with the study of Thewes et al (2005) reporting, using patient preference interviews, that modest gains in survival were sufficient for women under 40 with BC to find worthwhile a 5-year tamoxifen treatment.
While only rare CMTMR-labelled CMCs were detected in the kidneys and hearts of infused SNX animals at either early (1 day) or later (14 day) time points, CMTMR-labelled CMCs were abundant in the liver and spleen with a notable peak 4 days after administration but persistence throughout the time course of the study (Fig. 9).
HPV prevalence, incidence and persistence were among secondary objectives of the study.
