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It is written on the walls, in the persistence of signs.
Postoperative pneumonia was defined as the presence and persistence of signs of respiratory infection, such as fever, purulent sputum, leukocytosis, increased level of blood C-reactive protein, and worsening oxygenation with a new radiographic infiltrate [6].
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Treatment failure was defined as the persistence of clinical signs and symptoms of VO, i.e. fever, residual pain or neurological symptoms, or laboratory signs of inflammation with no other explanation, VO-related re-hospitalization, relapse or VO-related death.
Recurrence or persistence of clinical signs is common, suggestive of insulin ineffectiveness but is most likely associated with owner compliance/technique.
The persistence of motor signs into adulthood may indicate atypical neurological development [ 26].
Hypercontractured myofibres were also observed in β2KO mice (Fig. 1), suggesting the persistence of acute signs of injury.
The persistence of pathological signs was noted on MRI performed between 5 weeks and 19 months after diagnosis (n = 4).
These findings are in line with evidence that animals tend to adapt and thrive despite the persistence of neurological signs [ 8, 10, 22].
In contrast, the five studies with the highest clinical failure rates (range 38 83%, median 73%) defined clinical failure as persistence of otoscopic signs [ 15, 20- 23].
The latency of onset, individual susceptibility, phenomenologic expression of the purposeless movements, and persistence of TD signs between drug dosing, make the non-human primate TD model convincingly similar to the human condition, and best suited to address therapeutic issues.
This result has been reported by different studies [ 19] and corroborated by data from videocapsule endoscopy studies, consistent with the persistence of macroscopic signs of intestinal atrophy with a skip fashion [ 20].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com