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Understanding the mechanisms underlining pathogenicity and persistence of pathogens in human populations is an important aspect of disease epidemiology and control.
Comparative genomics and genomic tools have been used to identify virulence factors and genes involved in environmental persistence of pathogens.
In fact, the mechanism of acquisition of ESBL is not so obvious and the antibiotic exposure or the persistence of pathogens on inanimate surfaces could play an important role [26], even if the role of persistent environmental contamination as a reservoir for ESBL cross-transmission remains debatable.
Other studies on the persistence of pathogens in a water source, modeled using indicator organisms, have examined the effects of a number of attenuation parameters such as temperature, flow rate, particle size, pH, and sediment type [73], [74].
However, if cofeeding transmission rates in the field are lower than the measured values from laboratory studies (and possibly than the values used in [27]), our model predicts that vertical transmission plays an important role in the persistence of pathogens with short infectivity in mammalian hosts.
Environmental persistence of pathogens is also thought to facilitate vertical transmission [ 6, 7].
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The TA systems play a significant role in biofilm formation, antibiotic tolerance and persistence of pathogen inside the host cells.
Mycobacterium tuberculosis and Mycobacterium leprae cell wall lipids are more stable than aDNA and restrict permeability, thereby possibly aiding long-term persistence of pathogen aDNA.
Persistence of pathogen infections through late stages can worsen damage of the mammary gland and result in milk lost, or leave necrotic tissue and important injures [ 14].
Microbiological failure was defined as the persistence of pathogen(s) in laboratory samples or as the development of a new infection.
The inference is that soil nematodes can provide a protective micro-environment for human pathogens with health implications for the persistence of such pathogens in the soil.
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