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In other words, increasing or persistently high CRP concentrations, suggest persistence of inflammatory activity, and were associated with poor prognosis, whereas decreasing CRP levels suggests resolution of the inflammatory response, and was associated with a better outcome [ 15].
In addition, neurons newly generated by adult neurogenesis in the CA1 pyramidal layer also die, due to the persistence of inflammatory conditions [35].
The linkage between ERK activation and cell cycle progression induced by MIF can also shed light on inflammatory diseases in terms of persistence of inflammatory cells or growth of intrinsic cells.
It is possible that persistence of inflammatory infiltrate is related to the presence of diabetes, since diabetes leads to intense and prolonged inflammatory responses, possibly due to accentuated inflammatory cytokine expression [28], [29].
The persistence of inflammatory manifestations despite initial glucocorticoid treatment suggests that our patients had GVHD rather than engraftment syndrome.
High initial titres and persistence of inflammatory cytokines have been shown to be predictors of poor outcome [ 49].
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However, RA is a chronic inflammatory disease, and it is well known that the persistence of chronic inflammatory burden is of major importance in the development of CV events in these patients [ 20].
This persistence of the inflammatory process after smoking cessation is not well understood but represents a potential major therapeutic target.
The pulmonary attraction of these cells leads to the persistence of the inflammatory response and the accumulation of NF-kB within this cellular fraction.
The persistence of the inflammatory response in sinusitis is not only dependent on individual differences in host immune responses, but also on specific influence of these responses by local microbes.
Persistence of this inflammatory response has been associated with multi-organ failure.
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Justyna Jupowicz-Kozak
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