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It's going to take a persistence of focus to get to that part of the story, which is the most important part, especially with respect to preventing it from happening again.
The model, based upon Norman and Shallice's supervisory attention system, incorporates important features of human attentional control: selection of an intended task over a more salient automatic task; priming of future tasks that are anticipated; and appropriate levels of persistence of focus of attention.
As with most areas of life, fine and gracious living is an art and a science that eventuates best with a plan, priorities and persistence of focus and effort.
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Dose-dependent responses and persistence of foci make γ-H2AX assay a good biodosimeter for exposure of humans to ionizing radiation during radiological diagnostics or therapeutic treatments [ 47– 47].
However, due to the defect in the ATM gene which results in defective DNA DSB repair, there is a persistence of foci in the cells at 24 hrs post 2 Gy gamma irradiation; a result typical of many A-T cells.
Observation from clinical studies showed that about 80% septic patients had a persistence of infectious focus at the day they died [ 9].
Given that this mutant cell line, like the others tested here, exhibited no alteration in its ability to form damage-induced Rad51 foci, this raised the possibility that the T3232A mutation might promote the persistence of Rad51 foci after their formation.
Due to the position and distribution of Vilya3XHA foci on the SC between homologous chromosome arms during early/mid-pachytene, as well as the persistence of these foci into mid-pachytene, we speculated that Vilya might be localizing to sites of crossovers.
The persistence of γH2AX foci in high proportions of Rad21+/− crypt epithelial cells strongly suggests a deficiency in DSB repair and is consistent with the defect we showed in Rad21 mutant cells.
Elevated plasma CT indicates the persistence of neoplastic foci.
The rate of pCR or near complete (persistence of microscopic foci of adenocarcinoma in the rectal wall without lymph node) was 28% in the resected specimen.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com