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Thus, our persistence function describes a frustrated landscape in a 'persistence triangle' with vertices representing the three main strategies.
The persistence function therefore makes a mathematically explicit framework of persistence strategies for biomolecular systems, in which economy, flexibility and robustness engage in various trade-off solutions.
In the absence of a similar approach for protein domain organization, we start by defining a persistence function, which provides a heuristic argument for interpreting the MA power law.
We reiterate that the persistence function P for proteins and proteomes of eq. (3) depends solely on the length and number of domains, and can be apportioned into two separate terms.
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This paper presents a generic methodology to model and find periodic encounter patterns by using the auto-persistence function and detection techniques derived from it.
The importance of altering the host environment to facilitate persistence and function of transferred T cells and intrinsic properties of T cells that are selected or engineered for therapy in determining their fate in vivo are key issues that have recently emerged and are informing the design of the next generation of clinical trials.
The absence of IL-21 signaling profoundly affects GC persistence and function, influencing its proliferation, transition into memory B cells, and affinity maturation [ 20].
Whether the persistence of function rather than merely presence (anergy) of maternal CMI in the recipient requires antigen stimulation is to be determined.
CD25, CD40 and CD274 are transmembrane surface proteins involved in activation of macrophages and T cells upon binding, while IL-23 is essential for the persistence and function of Th17 cells [ 37, 38].
Longer-term persistence and function is provided by central memory phenotype T cells, and naïve T cells retain longer telomeres and the greatest proliferative potential (Hinrichs et al, 2011).
These exceptions to the rule offer natural experiments to explore the influence of host biology on symbiont persistence and functions.
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