Sentence examples for persistence and function of from inspiring English sources

The importance of altering the host environment to facilitate persistence and function of transferred T cells and intrinsic properties of T cells that are selected or engineered for therapy in determining their fate in vivo are key issues that have recently emerged and are informing the design of the next generation of clinical trials.

CD25, CD40 and CD274 are transmembrane surface proteins involved in activation of macrophages and T cells upon binding, while IL-23 is essential for the persistence and function of Th17 cells [ 37, 38].

The authors showed that the accumulation, persistence, and efficient function of Tregs were attributable to the expression of Bcl-xL in CD4 Tregs.

In line with this, a recent study reported that IL-7 selectively favors the expansion, persistence and effector function of T cells co-expressing a GD2-specific chimeric antigen receptor (CAR) and IL-7Rα53.

These exceptions to the rule offer natural experiments to explore the influence of host biology on symbiont persistence and functions.

Figure 1 illustrates the conditions for entrepreneurial entry and persistence as a function of initial information on entrepreneurial ability (λ 1 ) and acquired information (λ 2 ). Figure 1 Illustration of optimal occupation choices and returns in the first period (upper right corner) and in the second period (upper left corner).

The model shows how representing random movement, persistence by intrinsic means, or persistence by a function of VEGF concentrations alters phenotypic vessel length changes.

Switching between intensive and extensive search (with respectively low and high directional persistence) is a function of searcher's internal state represented as 'satiety' level depending on preceding consumption of prey items.

As a consequence of the limited persistence, homing and antitumour function of CAR gene-engineered T cells in early clinical studies, current strategies focus on generating cells with robust capacity to expand, persist, and migrate to the tumour, and on delivering them into a supportive immune milieu.

From an ecological point of view, our main results are the following: An explicit formula (23 ) and in different forms in (24 ) and (25 ), for the critical size of the favorable patch for persistence, as a function of the Malthusian parameters, the diffusion constant and the climate speed.

Instead, I show cases in which search persistence is a function of prior behavior (Chapter 1) and prior beliefs (Chapter 2).