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Further questions can be asked regarding the duration of the strategy, the reversibility of side effects under persisted therapy and the cross-reactivity of the combined antimitotics.
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We identified one SjS subject with a large expanded B-cell clone that was present prior to therapy and persisted after therapy.
This contrasts with RA, where synovitis has persisted despite therapy.
Neutropenic fever was treated with broad-spectrum antibiotics, and if fever persisted, antifungal therapy was changed.
Patient 2 was removed from the study after five cycles due to pruritus and erythema that persisted despite therapy.
When possible, salvage treatment (including afterloading, surgery, and chemotherapy) was provided in the event of documented relapse or if the disease persisted despite therapy.
Patients who persisted with therapy to the end of their observation time were censored on the last day of their follow-up.
When possible, salvage treatments (including afterloading, surgery and chemotherapy) were provided in the event of documented relapse or when the disease persisted despite therapy.
In order to describe the manner in which adherence and persistence with teriparatide therapy were related to economic outcomes, patients were grouped according to their adherence to the drug during the 12-month follow-up period, and whether they persisted with therapy during the same time frame (see Table 5).
Maintenance therapy does not normalize Th17 expansion, which persists after therapy is ceased.
Although imatinib is widely available, does not need prior authorization anymore, and is fully reimbursed, a large number of patients starting imatinib discontinued therapy within a short time or did not persist with therapy for the critical initial therapeutic period.
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