Whereas Rgs16 expression persisted, co-expression with CPA1 in these dedifferentiating pancreatic lobes was presumably transient, because these structures (and CPA1) were absent in PanIN and in older KIC mice with solid tumors occupying the entire transformed pancreas.
At 24 hpf, there was decreased expression in the floor plate while hypochord expression persisted with spreading ventral expression lateral to the dorsal aorta and posterior cardinal vein to the ventral somite boundary (Figure 2B and C).
At E17.5, expression persisted in PCs and Sall1 expression was found in cells in the cortical wall (Fig. 1C,F).
At early stage 32, Hoxd10 expression persisted in the posterior fins, but expression of Hoxd11 13 had decreased (Fig. 1D G).
However, with dorsomorphin treatment, significant levels of BryT expression persisted to day 4, when BryT expression was extinguished in controls (Figure 5A).
The ACAN gene expression persisted throughout the observation period but the expression pattern did not correlate with increased ACAN protein levels and 4(d)).
This expression persisted for up to 21 days in neurosphere culture and following differentiation, EGFP expression was maintained in ∼100% of cells (Figure 3B).
This high expression persisted through silique maturation, demonstrating a partial spatial separation of ProDH1 and ProDH2 expression in flowers.
Western blot analyses showed that cyclin D1 expression decreased after 2 h and remained suppressed, whereas cyclin E expression persisted.
In contrast, downregulation of Klf4 expression was impaired and 48 hr after the onset of differentiation, Klf4 expression persisted at around 40% of levels of controls in 2i.
