Regarding the argument (B) that OSC are not essential for neo-oogenesis since the oocytes persist in ovaries lacking OSC, we recently demonstrated that in rat ovaries lacking OSC, the oocytes originate by an alternate pathway, from medullary somatic stem cells; primordial follicles are formed in the juxtaposed (deep) ovarian cortex [ 72].
Finally, we determine that even in the absence of Notch inhibition, neurogenesis does not persist in embryos lacking NvSoxB(2).
Consistent with the recent discovery that telomeric DSB's resist DNA repair (Fumagalli et al, 2012), our data demonstrate that telomeric DDR foci persisted in cells lacking hTERT activity while non-telomeric foci were resolved within days.
Surprisingly, depolarization-induced calcium-dependent PKA transients persist in barrelless mice lacking AC1, the predominant calcium-dependent adenylate cyclase in RGCs, as well as in double knockout mice lacking both AC1 and AC8.
B) Oocytes persist in rat ovaries lacking ovarian surface epithelium (i.e. OSC).
Consistent with this result, circadian PRX over-oxidation cycles persist in red blood cells lacking Srx [ 27] but require proteasomal activity [ 27], and we speculate PRX-SO2/3 may similarly be degraded by the 20S proteasome.
Bacteria responsible belong mostly to cutaneous commensal flora, especially coagulase-negative staphylococci (CNS); these germs have the ability to adhere to indwelling medical devices and to persist in biofilms, but lack classical virulence factors.
Second, depolarization-induced PKA transients were decreased in amplitude but, surprisingly, persisted in knockout mice lacking the calcium dependent adenylate cyclase AC1 and in double knockout mice lacking both AC1 and AC8.
The isoflavonoid genistein facilitated opening of HCN1 and HCN2 channels, and this facilitation of channel opening persisted in HCN1 channels lacking only their CNBD, but not in channels missing the entire carboxy-terminal domain including the C-linker [32].
In some of these countries, however, it is also possible for a government to persist in office despite a lack of majority support.
For example, you persist in arguing, despite the lack of evidence, that higher taxes (within reason) will reduce the willingness to work.
