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Although a minority of infected people develops gastric cancer, this disease is the second leading cause of cancer death worldwide, partly because patients are not diagnosed until late-stage cancer is present and a poor prognosis [ 2]. H. pylori bacteria persist in spite of activation of the host's innate and adaptive immune response [ 6].
Abnormally high levels of T-cell activation can persist in HIV-infected subjects despite effective anti-retroviral therapy (ART) and has been associated with negative health outcomes.
Although antiretroviral therapy (ART) partially corrects immune dysfunction associated with HIV infection, abnormalities of immune activation markers persist in many patients [ 1- 3].
Since then, it has remained an unsolved problem how Brucella is able to persist in the infected host despite macrophage activation and a patently active and long lasting adaptive immunity.
Bartkowiak, K. et al. Disseminated tumor cells persist in the bone marrow of breast cancer patients through sustained activation of the unfolded protein response.
If AQP1 channel activation were due to nitric oxide modification, then the conductance should persist in ODQ.
He should persist in Palestine, too.
So why persist in this venture?
Substantial gaps persist in basic oceanographic knowledge.
Droughts persist in South America and Africa.
Additionally, the increased p38MAPK/MAPKAPK-2 activation persisted in H2O2-treated cells.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com