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There is clearly scope for numerous different interpretations of these recommendations but we limited our investigation to four different permutations (1) andM/CDC1 [6]; (2) CDC1 [1]; (3) ACSM/CDC2 [6]; and (4) CDC2 [1] as summarized in Table 1.
The program GENEPOP version 3.1 [ 48] was used to test for linkage disequilibrium among the ten loci analysed in this study (10 000 permutations, 1 000 dememorisation steps).
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The problem consisting in distributing atoms among one or several sets of disordered crystallographic sites was reformulated in terms of multinomial permutations.1 Let us consider a system with one disordered crystallographic site with multiplicity (K) and (N) different types of atoms occupying this site.
These stereo isomer conformers were then combined (2**5 = 32 maximum stereo permutations, 32 * 100,000 = maximum 3.2 million conformers).
For larger datasets (n≥200) RapidPT outperforms NaivePT (6× - 200×) on all datasets, and provides large speedups over SnPM13 when more than 10000 permutations (2× - 15×) are needed.
The CCA for six environmental variables and four ELHTs yielded a significant biplot based on a global permutation test (1000 permutations; p<0.01; Fig. 1).
To correct for multiple testing, false discovery rate (FDR) q value was also calculated from 100,000 permutations [41], [42].
For this reason Aβ42 analyses were performed using permutation based testing in PLINK (1 million permutations) [21].
Significance was tested by comparison with 95% confidence intervals from 1000 permutations [25].
Linkage analysis was performed using the Wilcoxon test, and statistical significance was estimated by permutations [31].
The individual NOT or negation functions N1, N2, N3 are represented between the permutations (1…24).
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