Detailed knowledge of the responses of individual genes to different stresses should permit refinements to these approaches that would be more consistently beneficial.
The documentation obtained from this early experience permitted refinement of procedures and development of a user manual.
The evaluations of the pilot study in phase II permitted refinement of the intervention, and adjustments were made before we considered it ready for clinical trial purposes.
Furthermore, our data permit refinement of carrier frequency and detection rate information for six major ethnic groups and the general, pan-ethnic population and address the call for a large-scale population screening study.
Taken together, these observations will help to improve our understanding of the diverse clinical course of SSc and permit refinement of existing outcome measures for the design of future clinical trials, in which the likelihood of observing a positive treatment effect with the drugs at our disposal will be maximized.
It is hoped that this comparison will permit further refinements in the theoretical calculations.
This refinement permitted further elaboration of effectiveness estimates, which we believe contributes to theoretical considerations around the control of other infectious diseases.
As for definitions of tuberculosis-associated IRIS, definitions for cryptococcal IRIS should be regarded as preliminary until further insights into the immunopathology of IRIS permit their refinement.
Studies based on initially broad operational definitions permit the refinement of the case definition as more knowledge is gained about the condition [8].
Insofar as mixing differs from society to society, if not between rural and urban sub-populations, more diverse subjects would permit continued refinement of methods to permit rapid, robust analysis and interpretation of alternative actions to address public health priorities.
This permitted further refinement of the cut-off value of PSA for the prediction of ABC transporters' substrate specificity of the pyrazolo[1,5- a]pyrimidines to 100 Å.
