At the same time, it is short enough to permit administration of 20 30 mCi of 99mTc without imposing a significant radiation dose to the patients.
However, the high toxicity of α-emitting radionuclides often does not permit administration of high activities for fear of normal tissue toxicity.
To increase the safety of the approach and thereby permit administration of larger T cell doses, we used a suicide gene, inducible caspase 9 (iCasp9), to transduce allodepleted T cells, permitting their destruction should administration have adverse effects.
Based on these studies, we hypothesize that specific molecular interactions between PS-containing bilayers and rFVIII may provide a basis for designing lipidic complexes that improve the stability, reduce the immunogenicity of rFVIII formulations, and permit administration by s.c. route.
administration for 5 days, have proved to be feasible and permit administration of higher daily doses (Pierga et al, 2003).
The targeting approach is generally conceived to permit administration of low, yet pharmacologically active, doses of drugs, thereby avoiding toxic reactions.
Nevertheless, there is a significant subset of patients whose overall condition does not permit administration of chemotherapy in a combined-modality treatment.
These are more thermodynamically stable, with a low reduction potential, and permit administration of a much higher dose of iron in a single administration without formation of large amounts of NTBI.
Douglas J. Besharov, a welfare expert at the American Enterprise Institute, said combining tougher work requirements with more training possibilities permitted the administration "to go left and right at the same time".
In Switzerland, castrating and disbudding male calves and small ruminants of any age are only permitted after administration of local anaesthesia (article 65 of the by-law on animal protection; Art. 65, TSchV).
