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The chapter also provides sufficient data for process synthesis of the flowsheet, which permits the optimization of the "base case" process design that can be used for preliminary economic evaluation of the process.
This protocol is an alternative to replace current STRs monoplex genotyping techniques; it permits the optimization of resources, improving specificity and sensitivity compared with common methods used to typify this parasite.
The computational search for possible mechanisms of 4-thiazolidinones anticancer activity has been studied together with the medical chemistry which permits the optimization of existing drugs [ 5].
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The pentameric structure of the CRP permitted the optimization of an assay with the lowest detectable concentration of 1 μg/L (7.5 pM) by using a single monoclonal antibody both for capture and as the tracer.
Studies of the genetic or environmental variability of the species would permit the optimization of yield and quality factors through the selection of genetic material or suitable production sites and management techniques.
Detailed elucidation of these mechanistic links may allow insight into oxidative stress-mediated apoptosis in cancer cells and permit the optimization of cancer-specific targeting therapies.
While these approaches permit the optimization of a vaccine for a specific population (i.e., a predefined HLA allotype distribution), the problem can also be reformulated to design a 'universal vaccine': a vaccine that provides maximum coverage on the whole world population (again, represented by its global allele frequencies) [ 2].
Finally, using a Taguchi signal-to-noise ratio permits the concurrent optimization of the process and the reduction of process variability.
A numerical model was developed in order to provide a simulation/analysis tool that permits the design optimization of the main system components.
This permits the stepwise optimization of therapy strategies in models gradually approaching the patients' situation with respect to tumor antigen tolerance.
The iterative inhibitor design and evaluation with assistance of the selectivity screen served to differentiate otherwise indistinguishable inhibitors permitting the simultaneous optimization of potency and selectivity.
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