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The C. cellulolyticum cellulosome is organised around the scaffolding protein CipC, which permits the binding of the different cellulosomal enzymes via interactions of dockerin cohesin domains.
This hydroxylation permits the binding of the von hippel-landau protein (pVHL) to HIF-1α.
HDAC activity deacetylates histone H3 lysine residues, which permits the binding of CoREST to the nucleosome [ 10].
This in turn leads to greater accessibility of the DNA in this region, which permits the binding of the transcription factor nuclear factor 1 (NF1), but it remained unclear which molecular processes are driven by NFI [ 4].
The peptide binding region (PBR) of MHC loci encodes a groove that permits the binding of specific antigens, and this region typically exhibits the highest sequence polymorphism within the gene [ 10].
Like every nuclear receptor, ARs are composed of three main domains [ 27]: a hypervariable N-terminal domain involved in transcriptional activation, a DNA-binding domain (also referred to as the C Domain) which permits the binding of receptor on target genes and a ligand-binding domain (also referred to as the E Domain).
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The area of MPA was locally activated to reactive esters to permit the binding of the protein.
Creation of the PXXXPR motif in mTTP (T302P) permitted the binding of mTTP to CIN85 (Fig. 4E3, lane 7).
Third, according to the results of a cross-docking test performed for TetR and the tetracycline derivatives (Table S1), the binding sites of the DV E protein and TetR permit the binding of the tetracycline derivatives.
However, when we replaced the threonine in the corresponding sequence in mTTP with proline (T302P), to recreate the human PXXXPR motif, it permitted the binding of mTTP to CIN85.
Histone deacetylase (HDAC) leads to condensation of nucleosome, while histone acetyl transferase (HAT), leads to hyperacetylation and relaxation of the nucleosome thereby permitting the binding of transcription factors to the DNA thus allowing gene transcription [7], [8], [9], [10].
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