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It permits screening large datasets or databases of chemical structures for those structures binding possibly to a drug target.
It also permits screening with pooled overlapping peptides, usage of clinical samples is economical, and lymphocytes maintain their viability, making it amenable for high-throughput proteome-wide antigen screening 31, 32.
Targeted massively parallel sequencing permits screening of genomic regions for multiple samples simultaneously, and thus is a powerful and cost-effective tool for characterizing mutations in contexts where multiple genes or pathways are involved[ 1, 13- 15].
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Rapid communication of images between the study sites and DARC permitted screening for eligibility and pre-treatment stratification of all patients prior to enrollment.
Because of their large arm sizes, however, BACVecs do not permit screening by conventional assays, such as long-range PCR or Southern blotting, that link the inserted targeting vector to the targeted locus.
Microsatellites are commonly used in genetic studies, but new methods, including restriction site associated DNA sequencing, now permit screening thousands of loci at comparable costs.
The differential expression and gene families databases permit screening and extraction of the entire dataset down to the single gene level, aided by application of a look-up and plotting tool.
Compatible plasmids were designed that permitted screening of the library of constructs in a strain prepared as competent cells co-expressing the bait.
Introduction of an HA tag at the C-terminus of recombinant Abi1 permitted screening of the clones as well as evaluation of relative levels of recombinant protein expression (Fig. 1C).
The experimental advantage of fish is their external development and the transparency of specific tissues even during larval stages, permitting screening under a fluorescence stereomicroscope.
Finally, the hypomorphic nature of the tefu ZIII-5190 allele should permit screening of enhancer/suppressor mutations, facilitating the genetic identification of new members of the ATM pathway.
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