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ATP released lumenally from umbrella cells is thought to play a role in autocrine signaling while release from the serosal surfaces permits interaction with stromal elements including afferent neurons and possibly the detrusor as well [2], [5].
In general, capping at the 5' ends minimizes mRNA degradation and most importantly permits interaction with ribosomes.
Phosphorylation of Smads 2 and 3 results in a conformational change and permits interaction with a common Smad (C-Smad) and initiates the translocation into the nucleus.
Structural changes at the AIS can therefore influence neuronal excitability on a rapid timescale that is directly comparable to, and permits interaction with, other well-described forms of plasticity.
FGF23 is an approximately 32-kDa protein with an N-terminal FGF homology domain and a novel 72-amino-acid C-terminus, which permits interaction with FGF receptor-α Klotho coreceptor-α Klothos in coreceptoranes of target tissues.
During undisturbed replication, PCNA is sumoylated by the Ubc9 Siz1 complex (Stelter and Ulrich 2003; Huang et al. 2007), which permits interaction with replicative Pols δ and ε and fast replisome progression at the replication forks.
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Given that the side chain of 457 is likely to contact the opposite end of the sugar, our data suggest that the E457Q mutation leads to allosteric changes in the binding site that permit interaction with 3DO-glc.
All three sites are oriented towards solvent, and two of the sites (P95S and S202L) are located in positions that may permit interaction with lipid since these residues are in close proximity to the LAPAO detergent in the crystal structure of ANT1 [16].
Furthermore, the apparently altered conformation of Irga6-K82A, whindersnders interaction with WT Irga6 in Y2H (see above), may permit interaction with Irgm3 even in the presence of GTP.
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In addition, they expose short linear peptide motifs of about 3 10 amino acids that permit interaction with structured domains in other proteins.
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