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The hyperdynamic states in our patients must have counterbalanced the low CO typical of Fontan cases to an extent similar to that observed in the report by Williams et al. but not to an extent sufficient to permit the extrapolation of the CO of healthy children to our cases.
Even though the limited number of donors does not permit the extrapolation of a generally valid model in this pilot study, it suggests that the reported regression model could be used to estimate a patient-specific ultimate strain or PYW from means CCL and CP.
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We have generated accurate estimates of the explicit costs of implementing such a program on a per-practice basis, which permits the extrapolation of these unit costs to other geographical domains.
Our study was performed with a large population-based database which contains computerized information entered by primary care physicians that permits the extrapolation of results to the general population.
This approach permits the extrapolation from tested cable nets to untested simulated cable nets, maintaining a basic configuration of constant parameters.
In addition, the large number of patients, the multi-institutional nature of the study population, and the median follow-up period of more than 7 years strengthen the reliability of the results and permit extrapolation of the findings to routine clinical practice.
Eruption rates averaged over a volcano's lifetime (Crisp 1984; Tomiya 1991; White et al. 2006) do not necessarily permit the forecasting of volcanic activity by simple extrapolation of these mean values.
In recognition that children may display developmentally unique differences in absorption, distribution, metabolism, and excretion (ADME) and resultantly exhibit variable patterns of drug sensitivity when compared to adults, the decision tree does not permit for extrapolation of PK and safety data between adults and children.
Additional comparative studies are critically needed on all aspects of carcinogenesis to permit effective extrapolation of carcinogenic potency data from animals to humans.
Owing to its physiologically based structure and parameterization, PBPK models permit for extrapolation of PK estimates between developmentally unique age groups as well as different species.
Theories permit the deduction of observational sentences.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com