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Given that the side chain of 457 is likely to contact the opposite end of the sugar, our data suggest that the E457Q mutation leads to allosteric changes in the binding site that permit interaction with 3DO-glc.
All three sites are oriented towards solvent, and two of the sites (P95S and S202L) are located in positions that may permit interaction with lipid since these residues are in close proximity to the LAPAO detergent in the crystal structure of ANT1 [16].
In addition, they expose short linear peptide motifs of about 3 10 amino acids that permit interaction with structured domains in other proteins.
To help others engage with this resource we also provide web-based tools that permit interaction with these and similar data sets.
rtTA requires interaction with doxycycline (Sigma Aldrich, Oakville, Ontario, Canada) to permit interaction with the TetO sequence to drive Cre expression resulting in the inactivation of PPARγ floxed alleles to generate a cartilage-specific PPARγ KO mice.
Informative meetings and training sessions within the context of a research group are valuable, since they allow students contact with other research methodologies and subjects and permit interaction with other researchers.
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The AMPAR rearrangement, triggered by TARPs, reflects a capacity of the AMPAR for dynamic reorganization that might permit interactions with other synaptic components, such as cadherins and pentraxins (Saglietti et al., 2007; Sia et al., 2007), to impact postsynaptic response properties via the NTD.
ATP released lumenally from umbrella cells is thought to play a role in autocrine signaling while release from the serosal surfaces permits interaction with stromal elements including afferent neurons and possibly the detrusor as well [2], [5].
In general, capping at the 5' ends minimizes mRNA degradation and most importantly permits interaction with ribosomes.
Phosphorylation of Smads 2 and 3 results in a conformational change and permits interaction with a common Smad (C-Smad) and initiates the translocation into the nucleus.
FGF23 is an approximately 32-kDa protein with an N-terminal FGF homology domain and a novel 72-amino-acid C-terminus, which permits interaction with FGF receptor-α Klotho coreceptor-α Klothos in coreceptoranes of target tissues.
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