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Greter, M. et al. Dendritic cells permit immune invasion of the CNS in an animal model of multiple sclerosis.
Breaking immunological tolerance is essential to permit immune responses against 'self' tumor-associated antigens such as Her2/ neu.
Either MHC down-regulation is insufficient on its own to permit immune evasion and needs an additional layer of protection, or the secreted cytokines directly or indirectly control MHC expression.
Damaged VECs could directly alter the permeability of the VEC barrier; permit immune cell targeting of DENV expressed by VECs; elicit immune cell-enhancing cytokine responses; and affect the rolling, adhesion, and transmigration of leukocytes and PLTs.
Similar(56)
Phase and antigenic variation of a number of surface components permits immune evasion during infection.
Viral suppression permits immune recovery and often delays the development of viral resistance [ 20].
The observed tumour regressions are probably brought about by (1) vascular damage in the tumour which permits immune defence mechanisms of the host to gain access to the tumour and (2) activation of macrophages present within the tumour.
To permit the immune system to detect these differences, our cells have evolved a remarkable mechanism, called the antigen processing and presentation pathway, that reveals intracellular contents on the surface.
It is speculated that T cell anergy as the result of a paucity of B7 costimulatory molecules, which may permit the immune evasion of the cancer, is one of the mechanisms responsible for the poor immunogenicity of tumor cells.
Data generated will permit comparison of immune responses to specific antigens and delivery systems in animal models and in humans.
Singh et al [56] have argued that complete suppression of CMV replication as a consequence of universal valganciclovir prophylaxis will likely not permit the host immune system to be exposed to naturally occurring low-level episodes of CMV antigenemia.
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