Below a certain threshold, this anemia becomes pathologic as it no longer permits a tissue oxygenation adequate for growth and development, and then, a blood transfusion is required.
A more detailed understanding of the mechanisms by which autoantibodies engage Fc receptors and complement to provoke pathology in a specific target tissue can permit a more tailored therapeutic intervention.
Furthermore, how can we interpret fossil evidence to permit a reconstruction of the "soft" tissues of the eyeball, as illustrated in Fig. 2?
The normal tissue tolerance does not permit a second full-dose course of radiotherapy to the entire breast after a second breast-conserving surgery (BCS).
Study of soft tissues of living species allows modeling of patterns in related extinct species, permitting a hypothetical soft tissue reconstruction, and therefore, an estimate of the appearance and function of tissues of fossils.
Time may, however, also allow beneficial adaptive processes that permit an individual to survive severe tissue hypoxia at levels that, encountered more acutely, might prove fatal.
Gap junction channels connect neighboring cells in nearly all tissues; they permit an exchange of metabolites, signaling molecules and ions, and regulate numerous physiological functions such as cell proliferation, differentiation and apoptosis (Goodenough et al., 1996).
By reactivating tissue-specific genes, differentiating therapy permits a new round of tissue-specific therapy.
The hypogastric nerve is dissected free from the uterosacral ligaments and the surrounding tissue, permitting a far more radical resection of the entire uterosacral ligaments and rectal pillars (Fig. 2 right).
However, if local policies did not permit submission of a tissue block, 10 serial unstained sections could be submitted.
