However, one advantage of global datasets is that they also permit a hypothesis-free approach.
Although our data are consistent with such a pattern, they do not permit a thorough test of this hypothesis.
Finally, because of the weak and inconsistent epidemiological and toxicological evidence for a causal association, this account requires that one rely heavily on the truth of toxi-cokinetic and mechanistic hypotheses that permit a plausible biological mode of action.
Future experiments in Drosophila may permit a direct test of this odor-coding hypothesis.
Our measure permits a natural null hypothesis test where the statistical significance of any proposed alignment hypothesis can be estimated.
This finding suggests that the analyzed gene pairs diverged relatively recently, permitting a test of the hypothesis that the observed rearrangements occurred according to the "permutation-by-duplication" model [ 20] or to the alternative model, involving intragenic relocation of gene segments.
The aromatase family offers an example where a combination of phylogenetic analysis, molecular evolutionary analysis, and chemical analysis set within the context of the paleontological and geological records, and supported by contemporary bioinformatics and molecular modeling tools, permits a higher order level of hypothesis generation concerning the function of proteins.
That information will permit future hypothesis generation about the biosynthetic pathways that are induced or repressed to account for differences in metabolite profiles.
The sample size was also too small to permit formal hypothesis testing or statistical analysis of association between impairment and biomechanical data.
The small sample size did not permit formal hypothesis testing therefore to compare differences between the study groups, the mean differences and associated confidence intervals were calculated using the t distribution.
Such strategies permit hypothesis generation around which healthcare delivery and organisational features warrant intervention, informing prospective cluster-randomised trials targeted at improving service organisation and delivery.
