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Although the precise molecular function of H3K4me2/3 in vivo and its contribution to gene expression remain poorly defined, these marks are generally considered permissive to active transcription.
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Furthermore, RBR E3 activity is permissive to the L104A mutant18.
This shift from a permissive to a mandatory basis is a shift of no inconsiderable significance.
The threshold for allowed color distortion is intentionally permissive to include chromatic shadows as well.
ULC plates are not permissive to cell adhesion.
Both regions also appear permissive to low-level transcription.
In the random telegraph model (upper panel), the gene exists in an inactive state which is non-permissive to transcription or an active state from which transcripts are produced (on-state indicated by red line).
H3K4me3 is often associated with transcriptionally permissive or active regions of chromatin, suggesting that recruitment and activation of KDM7B at these sites may limit repressive histone modifications from spreading into these regions [ 37– 39, 43, 44].
Finally, we compared chromatin enrichment profiles between the two classes of sites and found that accessible sites were enriched for epigenetic marks typically associated with permissive or active chromatin, while inaccessible sites showed no significant enrichment (Fig. 2a).
Permissive hypothermia and active cooling have been shown to reduce oxygen demands in patients experiencing stroke, cardiac arrest, cardiac surgery, severe trauma and other instances of ischemia and subsequent reperfusion [ 1- 4].
Ultimately the goal is to develop novel technologies that directly or indirectly aid in providing neuroprotection and/or a permissive environment and active signaling cues for guided axon growth.
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