Note also that even in the most permissive scenarios, the initial zoonotic infection was a dead end in more than 50% of the simulation runs.
Thus, both null models only partially contributed to explain the strong tendency to assemble FFLs with nadZs, even though we considered very permissive scenarios.
The spontaneous commitment picture emerging from our model studies is consistent with the "permissive" scenarios suggested in the context of hematopoiesis [ 43, 44].
Based on the most permissive 1919 scenario, we tested 10-fold reduced population size, balanced sex ratio (with 90% of the sexually active population in stable relationship), absence of GUD infections and universal circumcision.
Furthermore, the more permissive 1919 and 1929 scenarios yielded a bimodal distribution of outcomes indicating the effect of early stochastic events: after the first few transmissions, the epidemics that happened to reach the highly connected core of the sexual network can spread extensively; those that fail to do so, are likely to die out quickly.
Although previous work has suggested that the GigaBayes error model is accurate based on calibration to known sequence data (Quinlan et al. 2008), we considered the effect of two "worse-case" extremes on the magnitude of our θ estimates: a conservative worse-case scenario and a permissive worse-case scenario.
Figure 3 shows a relatively permissive consent profile for this scenario, with the most common response being "Just use it" (35 40%).
In the LASSO-favoring simulation scenario, application of a permissive univariate pre-filter reduced performance of the Elastic Net, by reducing the influence of the λ1 penalty, but in other situations was neutral.
Furthermore, the 1919 scenario proved to be consistently more permissive than the 1929 scenario, in spite of considerable population growth over the decade.
22 Thus, Mexico offers a unique epidemiological scenario to test whether more or less permissive abortion legislation affects maternal mortality in a population that shares the same history and culture and that has a homogeneous healthcare system.
